Sinclair Method Studies
This article examines the scientific foundation behind TSM, drawing on nearly three decades of peer‑reviewed trials, neuroimaging research, and systematic reviews.

The Sinclair Method (TSM) is a medically proven approach to reducing and overcoming alcohol dependence – one that flips conventional treatment on its head. Rather than asking you to quit drinking from day one, TSM invites you to do something far simpler: take a tablet of naltrexone one hour before drinking.

When it comes to treating Alcohol Use Disorder (AUD), many still believe that complete abstinence is the only path to recovery. But for thousands of people around the world, The Sinclair Method (TSM) offers a different way — one grounded in neuroscience, long-term results, and a powerful blend of medication and coaching.

Understanding the crucial role of support during The Sinclair Method (TSM). How a structured support programme enhances TSM effectiveness. Key components of a successful TSM support programme.
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